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Things to Know

10 Things to Remember:

1. Largest RNA virus genome

2. A cause of the common cold syndrome

3. SARS and MERS -- Possible pandemic virus

4. Translational frameshifting as method of translating polymerase

5. Subgenomic RNAs on 3’ end that are individually regulated and encode other proteins

6.  No vaccine nor antivirals

7. Spike glycoprotein determines tropism

8. Globally distributed

9. Zoonotic disease

10. Easily transmitted via respiratory route

5 New Findings:

1. R for MERS-CoV is between 0.8 and 1.3

2. At least 62% of human cases of MERS-CoV were not detected.

3. Anti-MERS-CoV antibodies have been found in the serum and milk of camels in the Middle East.

4. IFN-β and/or MPA  may be beneficial in treating MERS-CoV

5. Bone marrow stromal antigen 2 is a SARS Coronavirus antagonist; yet it is regulated by SARS-CoV ORF7a.

Relevant Links
Additional References

Vijgen, Leen et al. “Complete Genomic Sequence of Human Coronavirus OC43: Molecular Clock Analysis Suggests a Relatively Recent Zoonotic Coronavirus Transmission Event.” Journal of Virology 79.3 (2005): 1595–1604.


Knipe, David M., and Bernard N. Fields. "Coronaviridae." Fields Virology. Philadelphia: Lippincott Williams & Wilkins, 2007. N. pag.


Kahn, Jeffrey S., and Kenneth Mcintosh. "History and Recent Advances in Coronavirus Discovery." The Pediatric Infectious Disease Journal 24.Supplement (2005): S223-227.


Reusken CB, Farag EA et al. Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising

antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014. Euro Surveill. 2014;19(23):pii=20829.


Cauchemez, Simon, Christophe Fraser, Maria D Van Kerkhove, Christl A. Donnelly, Steven Riley, Andrew Rambaut, Vincent Enouf, Sylvie Van Der Werf, and Neil M. Ferguson. "Middle East Respiratory Syndrome Coronavirus: Quantification of the Extent of the Epidemic, Surveillance Biases, and Transmissibility." The Lancet Infectious Diseases 14.1 (2014): 50-56. Web.       


Hart, Brit J. et al. "Interferon-β and Mycophenolic Acid Are Potent Inhibitors of Middle East Respiratory Syndrome Coronavirus in Cell-based Assays." Journal of General Virology 95.3 (2014): 571-77.


Taylor, Justin. "BST-2 Restricts SARS Coronavirus and Is Antagonized by SARS-CoV ORF7a." University of Maryland Digital Archive. N.p., n.d.



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